Development of 5-(aminomethyl)pyrrole-2-carboxylic acid as a constrained surrogate of Gly-ΔAla and its application in peptidomimetic studies

被引：16

作者：

Chakraborty, TK ^{[1
]}

Mohan, BK ^{[1
]}

Kumar, SK ^{[1
]}

Kunwar, AC ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 14期

关键词：

peptide mimetics; dehydro amino acids; hydrogen bonding; conformation NMR;

D O I：

10.1016/S0040-4039(02)00342-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new peptidomimetic scaffold based on 5-(aminomethyl)pyrrole-2-carboxylic acid (1) is developed for the first time and used as a conformationally constrained surrogate of the Gly-DeltaAla dipeptide isostere (2) to prepare peptides 3 and 4. (C) 2002 Published by Elsevier Science.

引用

页码：2589 / 2592

页数：4

共 31 条

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