Differential role of regulatory T cells in early and late stages of pulmonary fibrosis

被引：93

作者：

Boveda-Ruiz, Daniel ^{[1
]}

D'Alessandro-Gabazza, Corina N. ^{[1
,2
]}

Toda, Masaaki ^{[1
]}

Takagi, Takehiro ^{[2
]}

Naito, Masahiro ^{[2
]}

Matsushima, Yuki ^{[1
]}

Matsumoto, Takahiro ^{[1
]}

Kobayashi, Tetsu ^{[2
]}

Gil-Bernabe, Paloma ^{[2
]}

Chelakkot-Govindalayathil, Ayshwarya-Lakshmi ^{[1
]}

Miyake, Yasushi ^{[1
]}

Yasukawa, Atsushi ^{[1
]}

Morser, John ^{[3
]}

Taguchi, Osamu ^{[2
]}

Gabazza, Esteban C. ^{[1
]}

机构：

[1] Mie Univ, Dept Immunol, Tsu, Mie 5148507, Japan

[2] Mie Univ, Dept Pulm & Crit Care Med, Tsu, Mie 5148507, Japan

[3] Stanford Univ, Sch Med, Div Hematol, CCSR 1155, Stanford, CA 94305 USA

来源：

IMMUNOBIOLOGY | 2013年 / 218卷 / 02期

关键词：

Lung fibrosis; Regulatory T cells; Bleomycin; LUNG FIBROSIS; BLEOMYCIN; OVEREXPRESSION; LYMPHOCYTES; CANCER; BETA; MICE;

D O I：

10.1016/j.imbio.2012.05.020

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Regulatory T cells (Tregs) are a specific subset of T lymphocytes that regulate the function of other subsets of lymphocytes. Contradictory results have been reported regarding the role of Tregs in lung fibrosis. We wished to clarify the role of Tregs in the early and late stages of bleomycin-induced lung fibrosis in mice by depleting them with anti-CD25+ antibody (PC61). Mice treated with PC61 in early stages had significantly decreased number of CD4+CD25+ T cells compared to mice treated with the isotype control. The number of inflammatory cells, the concentrations of collagen, TGF beta 1, the content of collagen and hydroxyproline in lung tissue were significantly reduced in PC61-treated mice compared to mice treated with the isotype control group. Pathological examination of the lung also disclosed reduced fibrotic changes and decreased fibrosis sore in the PC61 group compared to control group. By contrast, mice treated with PC61 in late stages of the disease showed more infiltration of inflammatory cells and higher fibrotic score and hydroxyproline content in the lungs than mice treated with the isotype control. Our results suggest that Tregs play a detrimental role in early stages but protective role in late stages of pulmonary fibrosis in mice. (C) 2012 Elsevier GmbH. All rights reserved.

引用

页码：245 / 254

页数：10

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