New anti-HIV-1, antimalarial, and antifungal compounds from Terminalia bellerica

被引：109

作者：

Valsaraj, R

Pushpangadan, P

Smitt, UW

Adsersen, A

Christensen, SB

Sittie, A

Nyman, U

Nielsen, C

Olsen, CE

机构：

[1] ROYAL DANISH SCH PHARM,DEPT MED CHEM,DK-2100 COPENHAGEN,DENMARK

[2] TROP BOT GARDEN & RES INST,DIV ETHNOPHARMACOL,THIRUVANANTHAPURAM 695562,KERALA,INDIA

[3] STATENS SERUM INST,DEPT VIROL,RETROVIRUS LAB,DK-2300 COPENHAGEN S,DENMARK

[4] ROYAL VET & AGR UNIV,DEPT CHEM,DK-1871 FREDERIKSBERG,DENMARK

来源：

JOURNAL OF NATURAL PRODUCTS | 1997年 / 60卷 / 07期

关键词：

D O I：

10.1021/np970010m

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A bioactivity-guided fractionation of an extract of Terminalia bellerica fruit rind led to the isolation of two new lignans named termilignan (1) and thannilignan (2), together with 7-hydroxy-3',4'-(methylenedioxy)flavan (3) and anolignan B (4). All four compounds possessed demonstrable anti-HIV-1, antimalarial, and antifungal activity in vitro.

引用

页码：739 / 742

页数：4

共 24 条

[1]

Avirutnant W, 1983, MAHIDOL U J PHARM SC, V10, P81

[2] CONSTITUENTS OF DRAGONS BLOOD .1. STRUCTURE AND ABSOLUTE CONFIGURATION OF NEW OPTICALLY ACTIVE FLAVANS [J].