The roles of ions on bone regeneration

被引：392

作者：

O'Neill, Edward ^{[1
,2
,3
]}

Awale, Guleid ^{[1
,2
,4
]}

Daneshmandi, Leila ^{[1
,2
,5
]}

Umerah, Obum ^{[1
,2
,5
]}

Lo, Kevin W. -H. ^{[1
,2
,3
,5
,6
,7
,8
]}

机构：

[1] Univ Connecticut, Hlth Ctr, Sch Med, Inst Regenerat Engn, Farmington, CT 06030 USA

[2] Univ Connecticut, Hlth Ctr, Sch Med, Raymond & Beverly Sackler Ctr Biomed Biol Phys &, Farmington, CT 06030 USA

[3] Univ Connecticut, Hlth Ctr, Sch Med, Dept Med,Div Endocrinol, Farmington, CT 06030 USA

[4] Univ Connecticut, Sch Engn, Dept Chem Engn, Storrs, CT 06268 USA

[5] Univ Connecticut, Sch Engn, Dept Biomed Engn, Storrs, CT 06268 USA

[6] Univ Connecticut, Hlth Ctr, UConn Stem Cell Inst, Farmington, CT 06030 USA

[7] Univ Connecticut, Hlth Ctr, Sch Med, Dept Orthopaed Surg, Farmington, CT 06030 USA

[8] Univ Connecticut, Hlth Ctr, Connecticut Inst Clin & Translat Sci, Farmington, CT 06030 USA

来源：

DRUG DISCOVERY TODAY | 2018年 / 23卷 / 04期

基金：

美国国家科学基金会;

关键词：

BIOACTIVE GLASS SCAFFOLDS; OSTEOGENIC ACTIVITY; OSTEOBLAST DIFFERENTIATION; CERAMIC SCAFFOLDS; MORPHOGENETIC PROTEIN-2; TRICALCIUM PHOSPHATE; CELL-PROLIFERATION; COMPOSITE SCAFFOLD; CALCIUM-PHOSPHATE; TIO2; COATINGS;

D O I：

10.1016/j.drudis.2018.01.049

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Bone scientists are actively investigating a range of methods to promote skeletal tissue regeneration. A review of recent literature has revealed that several ions are uniquely capable of inducing stem cell differentiation down desired lineages. There exists enormous promise for these ions to be used in bone regenerative medicine. Given that these ions can be released from biodegradable polymeric materials, their long-term delivery can be achieved through a variety of controlled-release strategies compared with the relatively few options available for expensive and fragile polypeptide-based growth factors. In this review, we highlight the developments in using ions in conjunction with biomaterials for bone regeneration.

引用

页码：879 / 890

页数：12

共 118 条

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Pyrophosphate inhibits mineralization of osteoblast cultures by binding to mineral, up-regulating osteopontin, and inhibiting alkaline phosphatase activity [J].