Increased interleukin-1 and interleukin-1 receptor antagonist levels in cervical mucus in the ovulatory phase in comparison with the follicular phase

被引：13

作者：

Kanai, T

FukudaMiki, M

Shimoya, K

Azuma, C

Hashimoto, K

Nobunaga, T

Tokugawa, Y

Tsujimoto, M

Saji, F

Murata, Y

机构：

[1] OSAKA UNIV,SCH MED,DEPT OBSTET & GYNECOL,SUITA,OSAKA 565,JAPAN

[2] OSAKA POLICE HOSP,DEPT PATHOL,OSAKA,JAPAN

来源：

GYNECOLOGIC AND OBSTETRIC INVESTIGATION | 1997年 / 43卷 / 03期

关键词：

IL-1 receptor antagonist; cervical mucus; ovulation; interleukin-1;

D O I：

10.1159/000291847

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Interleukin-1 (IL-1) receptor antagonist (IL-1ra) levels in the cervical mucus of women in the ovulatory phase are significantly higher than those in the follicular phase. IL-1 titers of women in the ovulatory phase are also significantly higher than those in the follicular phase, A positive correlation between IL-1ra and IL-1 levels in the cervical mucus was observed. Immunohistochemistry using an anti-IL-1ra monoclonal antibody revealed positive staining in the epithelial cells of the endocervix. These results suggest that IL-1ra from cervical epithelial cells protects the reproductive system from the toxicity of IL-1 produced in the endocervix.

引用

页码：166 / 170

页数：5

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