AMPK: a metabolic gauge regulating whole-body energy homeostasis

被引：437

作者：

Lage, Ricardo ^{[1
]}

Dieguez, Carlos ^{[1
]}

Vidal-Puig, Antonio ^{[2
]}

Lopez, Miguel ^{[1
]}

机构：

[1] Univ Santiago de Compostela, Sch Med, Dept Physiol, Santiago De Compostela 15782, Spain

[2] Univ Cambridge, Addenbrookes Hosp, Inst Metab Sci, Metab Res Labs, Cambridge CB2 0QQ, England

来源：

TRENDS IN MOLECULAR MEDICINE | 2008年 / 14卷 / 12期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1016/j.molmed.2008.09.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

AMP-activated protein kinase (AMPK) is the downstream component of a kinase cascade that acts as a gauge of cellular energy levels. Over the last few years, accumulating evidence has demonstrated that AMPK is also involved in the regulation of energy balance at the whole-body level by responding to hormones and nutrient signals, which leads to changes in energy homeostasis. The physiological relevance of this new role of AMPK is demonstrated by the fact that impairment of AMPK function is associated with metabolic alterations, insulin resistance, obesity, hormonal disorders and cardiovascular disease. Here, we summarize the role of AMPK in the regulation of energy homeostasis. Understanding this key enzyme and its tissue-specific regulation will provide new targets for the treatment of metabolic disorders.

引用

页码：539 / 549

页数：11

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