The Population Genetics of dN/dS

被引:646
作者
Kryazhimskiy, Sergey [1 ]
Plotkin, Joshua B. [1 ,2 ]
机构
[1] Univ Penn, Dept Biol, Philadelphia, PA 19104 USA
[2] Univ Penn, Program Appl Math & Computat Sci, Philadelphia, PA 19104 USA
来源
PLOS GENETICS | 2008年 / 4卷 / 12期
关键词
D O I
10.1371/journal.pgen.1000304
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Evolutionary pressures on proteins are often quantified by the ratio of substitution rates at non-synonymous and synonymous sites. The dN/dS ratio was originally developed for application to distantly diverged sequences, the differences among which represent substitutions that have fixed along independent lineages. Nevertheless, the dN/dS measure is often applied to sequences sampled from a single population, the differences among which represent segregating polymorphisms. Here, we study the expected dN/dS ratio for samples drawn from a single population under selection, and we find that in this context, dN/dS is relatively insensitive to the selection coefficient. Moreover, the hallmark signature of positive selection over divergent lineages, dN/dS. 1, is violated within a population. For population samples, the relationship between selection and dN/dS does not follow a monotonic function, and so it may be impossible to infer selection pressures from dN/dS. These results have significant implications for the interpretation of dN/dS measurements among population-genetic samples.
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页数:10
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