Water-Fat MRI for Assessing Changes in Bone Marrow Composition Due to Radiation and Chemotherapy in Gynecologic Cancer Patients

被引：77

作者：

Bolan, Patrick J. ^{[1
]}

Arentsen, Luke ^{[2
]}

Sueblinvong, Thanasak ^{[3
]}

Zhang, Yan ^{[4
]}

Moeller, Steen ^{[1
]}

Carter, Jori S. ^{[3
]}

Downs, Levi S., Jr. ^{[3
]}

Ghebre, Rahel ^{[3
]}

Yee, Douglas ^{[4
,5
]}

Froelich, Jerry ^{[1
]}

Hui, Susanta ^{[4
,6
]}

机构：

[1] Univ Minnesota, Dept Radiol, Ctr Magnet Resonance Res, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Dept Med Phys, Minneapolis, MN USA

[3] Univ Minnesota, Dept Obstet & Gynecol, Minneapolis, MN 55455 USA

[4] Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN USA

[5] Univ Minnesota, Dept Med, Minneapolis, MN 55455 USA

[6] Univ Minnesota, Dept Therapeut Radiol, Minneapolis, MN USA

来源：

JOURNAL OF MAGNETIC RESONANCE IMAGING | 2013年 / 38卷 / 06期

基金：

美国国家卫生研究院;

关键词：

bone marrow; water-fat imaging; Dixon MRI; QUANTIFICATION; SPECTROSCOPY; AGE; DECOMPOSITION; OSTEOPOROSIS; RECOVERY; VOLUME; DAMAGE; NOISE; WOMEN;

D O I：

10.1002/jmri.24071

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

100231 [临床病理学]; 100902 [航空航天医学];

摘要：

PurposeTo assess the feasibility of using fat-fraction imaging for measuring marrow composition changes over large regions in patients undergoing cancer therapy. Materials and MethodsThirteen women with gynecologic malignancies who were to receive radiation and/or chemotherapy were recruited for this study. Subjects were imaged on a 3T magnetic resonance (MR) scanner at baseline (after surgery but before radiation or chemotherapy), 6 months, and 12 months after treatment. Water-fat imaging was used to generate high-resolution, 3D signal fat fraction (sFF) maps extending from mid-femur to L3. Treatment changes were assessed by measuring marrow sFF in the L4 vertebra, femoral necks, and control tissues. ResultsPretreatment and 6-month scans were compared in nine women. sFF increased significantly in both the L4 vertebral marrow (P = 0.04) and the femoral necks (P = 0.03), while no significant change was observed in control regions. Qualitatively, chemotherapy changes were more uniform in space, whereas the radiation-induced changes were largest in marrow regions inside and close to the target radiation field. ConclusionWater-fat MRI is sensitive to changes in red/yellow marrow composition, and can be used for quantitative and qualitative assessment of treatment-induced marrow damage. J. Magn. Reson. Imaging 2013;38:1578-1584. (c) 2013 Wiley Periodicals, Inc.

引用

页码：1578 / 1584

页数：7

共 37 条

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Does vertebral bone marrow fat content correlate with abdominal adipose tissue, lumbar spine bone mineral density, and blood biomarkers in women with type 2 diabetes mellitus? [J].