Sequence of HLA-A*6808

被引:18
作者
Cox, ST
Argüello, JR
Marsh, SGE
Lau, M
Kwan, PL
Madrigal, JA
Little, AM
机构
[1] Royal Free Hosp, Anthony Nolan Res Inst, London NW3 2QG, England
[2] Royal Free Hosp, Sch Med, Dept Haematol, London NW3 2QG, England
[3] Univ Calif Los Angeles, Los Angeles, CA USA
[4] Sacramento Blood Ctr, Sacramento, CA USA
[5] Univ London Imperial Coll Sci Technol & Med, Sch Med, London, England
来源
TISSUE ANTIGENS | 1999年 / 53卷 / 06期
关键词
HLA-A*6808; sequence-based typing; reference strand conformation analysis;
D O I
10.1034/j.1399-0039.1999.530614.x
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
A novel HLA-A*68 allele was identified by reference strand conformation analysis of a DNA sample studied for the International Cell Exchange program. Direct sequencing of HLA-A locus PCR products confirmed the presence of A*6602 and an A*68 allele which differed from A*68011 by two nucleotides at positions 538 and 539. The presence of this sequence motif in this allele which has been named A*6808 was verified by DNA sequencing of full-length A*6808 clones. No other coding differences between A*68011 and A*6808 were identified. The two nucleotide substitutions found in A*6808 effect an amino acid difference in the encoded protein at residue 156 within the peptide binding site which may evoke alloreactive immune response after HLA-A68 mismatched transplants.
引用
收藏
页码:597 / 600
页数:4
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