The International Costs and Utilities Related to Osteoporotic Fractures Study (ICUROS)-quality of life during the first 4 months after fracture

被引：156

作者：

Borgstrom, F. ^{[1
]}

Lekander, I. ^{[1
]}

Ivergard, M. ^{[2
]}

Strom, O. ^{[1
]}

Svedbom, A. ^{[2
]}

Alekna, V. ^{[3
,4
]}

Bianchi, M. L. ^{[5
]}

Clark, P. ^{[6
,7
]}

Curiel, M. D. ^{[8
,9
]}

Dimai, H. P. ^{[10
]}

Jurisson, M. ^{[11
]}

Kallikorm, R. ^{[11
]}

Lesnyak, O. ^{[12
]}

McCloskey, E. ^{[13
]}

Nassonov, E. ^{[14
]}

Sanders, K. M. ^{[15
]}

Silverman, S. ^{[16
]}

Tamulaitiene, M. ^{[3
]}

Thomas, T. ^{[17
]}

Tosteson, A. N. A. ^{[18
]}

Jonsson, B. ^{[19
]}

Kanis, J. A. ^{[20
]}

机构：

[1] Karolinska Inst, LIME MMC, Stockholm, Sweden

[2] OptumInsight, Stockholm, Sweden

[3] Vilnius State Univ, Fac Med, Vilnius, Lithuania

[4] State Res Inst Ctr Innovat Med, Vilnius, Lithuania

[5] Ist Auxol Italiano IRCCS, Bone Metab Unit, Milan, Italy

[6] Univ Nacl Autonoma Mexico, Clin Epidemiol Unit, Hosp Infantil Federico Gomez, Mexico City, DF, Mexico

[7] Univ Nacl Autonoma Mexico, Fac Med, Mexico City, DF, Mexico

[8] Fdn Jimenez Diaz, Serv Med Interna Enfermedades Metab Oseas, E-28040 Madrid, Spain

[9] Univ Autonoma Madrid, Catedra Enfermedades Metab Oseas, Madrid, Spain

[10] Med Univ Graz, Graz, Austria

[11] Univ Tartu, Fac Med, EE-50090 Tartu, Estonia

[12] Ural State Med Acad, Ekaterinburg, Russia

[13] Univ Sheffield, Acad Unit Bone Metab, Metab Bone Ctr, Sheffield, S Yorkshire, England

[14] RAMS, FSBI Res Inst Rheumatol, Moscow, Russia

[15] Univ Melbourne, Dept Med, NW Acad Ctr, Melbourne, Vic, Australia

[16] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA

[17] CHU St Etienne, INSERM, U1059, St Etienne, France

[18] Geisel Sch Med Dartmouth, Dartmouth Inst Hlth Policy & Clin Practice, Lebanon, OH USA

[19] Stockholm Sch Econ, S-11383 Stockholm, Sweden

[20] Univ Sheffield, WHO Collaborating Ctr Metab Bone Dis, Sheffield, S Yorkshire, England

来源：

OSTEOPOROSIS INTERNATIONAL | 2013年 / 24卷 / 03期

基金：

英国医学研究理事会;

关键词：

Costs; Fracture; Osteoporosis; Quality of life; QUALITY-OF-LIFE; HIP FRACTURE; POSTMENOPAUSAL WOMEN; COGNITIVE IMPAIRMENT; ELDERLY-PATIENTS; VALUES; IMPACT; EPIDEMIOLOGY; RISK;

D O I：

10.1007/s00198-012-2240-2

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

The quality of life during the first 4 months after fracture was estimated in 2,808 fractured patients from 11 countries. Analysis showed that there were significant differences in the quality of life (QoL) loss between countries. Other factors such as QoL prior fracture and hospitalisation also had a significant impact on the QoL loss. The International Costs and Utilities Related to Osteoporotic Fractures Study (ICUROS) was initiated in 2007 with the objective of estimating costs and quality of life related to fractures in several countries worldwide. The ICUROS is ongoing and enrols patients in 11 countries (Australia, Austria, Estonia, France, Italy, Lithuania, Mexico, Russia, Spain, UK and the USA). The objective of this paper is to outline the study design of ICUROS and present results regarding the QoL (measured using the EQ-5D) during the first 4 months after fracture based on the patients that have been thus far enrolled ICUROS. ICUROS uses a prospective study design where data (costs and quality of life) are collected in four phases over 18 months after fracture. All countries use the same core case report forms. Quality of life was collected using the EQ-5D instrument and a time trade-off questionnaire. The total sample for the analysis was 2,808 patients (1,273 hip, 987 distal forearm and 548 vertebral fracture). For all fracture types and countries, the QoL was reduced significantly after fracture compared to pre-fracture QoL. A regression analysis showed that there were significant differences in the QoL loss between countries. Also, a higher level of QoL prior to the fracture significantly increased the QoL loss and patients who were hospitalised for their fracture also had a significantly higher loss compared to those who were not. The findings in this study indicate that there appear to be important variations in the QoL decrements related to fracture between countries.

引用

页码：811 / 823

页数：13

共 35 条

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