Flow Microwave Technology and Microreactors in Synthesis

被引：47

作者：

Baxendale, Ian R. ^{[1
]}

Hornung, Christian ^{[2
]}

Ley, Steven V. ^{[3
]}

Molina, Juan de Mata Munoz ^{[3
]}

Wikstrom, Anders ^{[4
]}

机构：

[1] Univ Durham, Dept Chem, Durham DH1 3LE, England

[2] CSIRO Mat Sci & Engn, Clayton, Vic 3169, Australia

[3] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

[4] Biotage Sweden AB, SE-75318 Uppsala, Sweden

来源：

AUSTRALIAN JOURNAL OF CHEMISTRY | 2013年 / 66卷 / 02期

关键词：

ASSISTED ORGANIC-SYNTHESIS; IONIC LIQUID; CURTIUS REARRANGEMENT; COUMARIN SYNTHESIS; CONCISE SYNTHESIS; BATCH; ACID; CHEMISTRY; CATALYST;

D O I：

10.1071/CH12365

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A bespoke microwave reactor with a glass containment cell has been developed for performing continuous flow reactions under microwave heating. The prototype unit has been evaluated using a series of standard organic chemical transformations enabling scale-up of these chemical processes. As part of the development, a carbon-doped PTFE reactor insert was utilized to allow the heating of poorly absorbing reaction media, increasing the range of solvents and scope of reactions that can be performed in the device.

引用

收藏

页码：131 / 144

页数：14

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