An updated systematic review of the role of host genetics in susceptibility to influenza

被引：34

作者：

Horby, Peter ^{[1
]}

Nguyen, Nhu Y. ^{[1
]}

Dunstan, Sarah J. ^{[1
]}

Baillie, John Kenneth ^{[2
]}

机构：

[1] Univ Oxford, Wellcome Trust Major Overseas Programme, Clin Res Unit, Hanoi, Vietnam

[2] Univ Edinburgh, Roslin Inst, Edinburgh, Midlothian, Scotland

来源：

INFLUENZA AND OTHER RESPIRATORY VIRUSES | 2013年 / 7卷

基金：

英国惠康基金;

关键词：

Animal model; host genetics; human influenza; susceptibility; systematic review; QUANTITATIVE TRAIT LOCI;

D O I：

10.1111/irv.12079

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The World Health Organization has identified studies of the role of host genetics on susceptibility to severe influenza as a priority. A systematic review was conducted in June 2011 to summarise the evidence on the role of host genetics in susceptibility to influenza, and this report updates that previously published review. Animal studies suggest that genetic control of susceptibility to severe influenza in mice is complex and not controlled by a single locus, but there is encouraging evidence that some of the host genetic determinants of susceptibility to severe disease may be common across influenza subtypes. Although a number of studies on genetic susceptibility to influenza in humans have been published recently, all are underpowered and unreplicated, so do not provide robust statistical evidence of an association between the identified genetic loci and susceptibility. One study does however present convincing functional evidence for an important role for IFITM3 in susceptibility to severe influenza in mice, and some evidence that this may also be important in human A/H1N1/pdm2009 infection.

引用

页码：37 / 41

页数：5

共 18 条

[1]

[Anonymous], WHO PUBL HLTH RES AG

[2] Role of tumor necrosis factor gene single nucleotide polymorphisms in the natural course of 2009 influenza A H1N1 virus infection [J].

Antonopoulou, Anastasia ;

Baziaka, Fotini ;

Tsaganos, Thomas ;

Raftogiannis, Maria ;

Koutoukas, Pantelis ;

Spyridaki, Aikaterini ;

Mouktaroudi, Maria ;

Kotsaki, Antigone ;

Savva, Athina ;

Georgitsi, Marianna ;

Giamarellos-Bourboulis, Evangelos J. .

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2012, 16 (03) :E204-E208

[3]

Bautista E, 2010, NEW ENGL J MED, V362, P1708, DOI 10.1056/NEJMra1000449

[4] Mapping of Clinical and Expression Quantitative Trait Loci in a Sex-Dependent Effect of Host Susceptibility to Mouse-Adapted Influenza H3N2/HK/1/68 [J].

Boivin, Gregory A. ;

Pothlichet, Julien ;

Skamene, Emil ;

Brown, Earl G. ;

Loredo-Osti, J. Concepcion ;

Sladek, Robert ;

Vidal, Silvia M. .

JOURNAL OF IMMUNOLOGY, 2012, 188 (08) :3949-3960

[5] H5N1 Influenza Virus Pathogenesis in Genetically Diverse Mice Is Mediated at the Level of Viral Load [J].

Boon, Adrianus C. M. ;

Finkelstein, David ;

Zheng, Ming ;

Liao, Guochun ;

Allard, John ;

Klumpp, Klaus ;

Webster, Robert ;

Peltz, Gary ;

Webby, Richard J. .

MBIO, 2011, 2 (05)

[6] Host Genetic Variation Affects Resistance to Infection with a Highly Pathogenic H5N1 Influenza A Virus in Mice [J].

Boon, Adrianus C. M. ;

deBeauchamp, Jennifer ;

Hollmann, Anna ;

Luke, Jennifer ;

Kotb, Malak ;

Rowe, Sarah ;

Finkelstein, David ;

Neale, Geoffrey ;

Lu, Lu ;

Williams, Robert W. ;

Webby, Richard J. .

JOURNAL OF VIROLOGY, 2009, 83 (20) :10417-10426

[7] Expression Quantitative Trait Loci for Extreme Host Response to Influenza A in Pre-Collaborative Cross Mice [J].

Bottomly, Daniel ;

Ferris, Martin T. ;

Aicher, Lauri D. ;

Rosenzweig, Elizabeth ;

Whitmore, Alan ;

Aylor, David L. ;

Haagmans, Bart L. ;

Gralinski, Lisa E. ;

Bradel-Tretheway, Birgit G. ;

Bryan, Janine T. ;

Threadgill, David W. ;

de Villena, Fernando Pardo-Manuel ;

Baric, Ralph S. ;

Katze, Michael G. ;

Heise, Mark ;

McWeeney, Shannon K. .

G3-GENES GENOMES GENETICS, 2012, 2 (02) :213-221

[8] Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls [J].

Burton, Paul R. ;

Clayton, David G. ;

Cardon, Lon R. ;

Craddock, Nick ;

Deloukas, Panos ;

Duncanson, Audrey ;

Kwiatkowski, Dominic P. ;

McCarthy, Mark I. ;

Ouwehand, Willem H. ;

Samani, Nilesh J. ;

Todd, John A. ;

Donnelly, Peter ;

Barrett, Jeffrey C. ;

Davison, Dan ;

Easton, Doug ;

Evans, David ;

Leung, Hin-Tak ;

Marchini, Jonathan L. ;

Morris, Andrew P. ;

Spencer, Chris C. A. ;

Tobin, Martin D. ;

Attwood, Antony P. ;

Boorman, James P. ;

Cant, Barbara ;

Everson, Ursula ;

Hussey, Judith M. ;

Jolley, Jennifer D. ;

Knight, Alexandra S. ;

Koch, Kerstin ;

Meech, Elizabeth ;

Nutland, Sarah ;

Prowse, Christopher V. ;

Stevens, Helen E. ;

Taylor, Niall C. ;

Walters, Graham R. ;

Walker, Neil M. ;

Watkins, Nicholas A. ;

Winzer, Thilo ;

Jones, Richard W. ;

McArdle, Wendy L. ;

Ring, Susan M. ;

Strachan, David P. ;

Pembrey, Marcus ;

Breen, Gerome ;

St Clair, David ;

Caesar, Sian ;

Gordon-Smith, Katherine ;

Jones, Lisa ;

Fraser, Christine ;

Green, Elain K. .

NATURE, 2007, 447 (7145) :661-678

[9] The Lower Serum Immunoglobulin G2 Level in Severe Cases than in Mild Cases of Pandemic H1N1 2009 Influenza Is Associated with Cytokine Dysregulation [J].

Chan, Jasper Fuk-Woo ;

To, Kelvin Kai-Wang ;

Tse, Herman ;

Lau, Candy Choi-Yi ;

Li, Iris Wai-Sum ;

Hung, Ivan Fan-Ngai ;

Chan, Kwok-Hung ;

Cheng, Vincent Chi-Chung ;

Lai, Thomas Sik-To ;

Woo, Patrick Chiu-Yat ;

Chan, Eric Yuk-Tat ;

Yuen, Kwok-Yung .

CLINICAL AND VACCINE IMMUNOLOGY, 2011, 18 (02) :305-310

[10] IFITM3 restricts the morbidity and mortality associated with influenza [J].

Everitt, Aaron R. ;

Clare, Simon ;

Pertel, Thomas ;

John, Sinu P. ;

Wash, Rachael S. ;

Smith, Sarah E. ;

Chin, Christopher R. ;

Feeley, Eric M. ;

Sims, Jennifer S. ;

Adams, David J. ;

Wise, Helen M. ;

Kane, Leanne ;

Goulding, David ;

Digard, Paul ;

Anttila, Verneri ;

Baillie, J. Kenneth ;

Walsh, Tim S. ;

Hume, David A. ;

Palotie, Aarno ;

Xue, Yali ;

Colonna, Vincenza ;

Tyler-Smith, Chris ;

Dunning, Jake ;

Gordon, Stephen B. ;

Smyth, Rosalind L. ;

Openshaw, Peter J. ;

Dougan, Gordon ;

Brass, Abraham L. ;

Kellam, Paul .

NATURE, 2012, 484 (7395) :519-U146

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