Effects of vitamins A and E on methylazoxymethanol-induced mutagenesis in Salmonella typhimurium strain TA100

被引：19

作者：

Tavan, E ^{[1
]}

Maziere, S ^{[1
]}

Narbonne, JF ^{[1
]}

Cassand, P ^{[1
]}

机构：

[1] UNIV BORDEAUX 1,LAB TOXICOL ALIMENTAIRE,F-33405 TALENCE,FRANCE

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 1997年 / 377卷 / 02期

关键词：

methylazoxymethanol; mutagenesis; antimutagenesis; vitamin A; vitamin E; colon cancer;

D O I：

10.1016/S0027-5107(97)00079-1

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The aim of this study is to report the antimutagenic effect of vitamin A and vitamin E towards methylazoxymethanol (MAM)-induced mutagenesis in Salmonella typhimurium strain TA100 sensitive to alkylating agents. In order to characterize different levels of action of these two fat-soluble vitamins towards the mutagenicity of MAM, several assays have been considered to show the antimutagenic effect and the possible interactions of vitamins with MAM or with the bacteria. Thus, for each vitamin, three different assays with three different incubations have been conducted: (i) MAM, bacteria and vitamins together, (ii) MAM and vitamins, (iii) bacteria and vitamins. The results showed that both vitamins A and E present an antimutagenic effect towards MAM induced mutagenesis. alpha-Tocopherol seems to have an action directly on to the mutagenic agent, whereas the action of retinol is likely due to a protection of the bacterial genoma against MAM. These in vitro results could help to interpret results of colon carcinogenesis studies using animals induced by 1,2-dimethylhydrazine and fed vitamins supplemented diet.

引用

页码：231 / 237

页数：7

共 27 条

[1] EFFECT OF VITAMIN-A, VITAMIN-C AND GLUTATHIONE ON THE MUTAGENICITY OF BENZO[A]PYRENE MEDIATED BY S9 FROM VITAMIN-A-DEFICIENT RATS [J].

ALZIEU, P ;

CASSAND, P ;

COLIN, C ;

GROLIER, P ;

NARBONNE, JF .

MUTATION RESEARCH, 1987, 192 (04) :227-231

[2] VITAMIN-A [J].

BATES, CJ .

LANCET, 1995, 345 (8941) :31-35

[3] SCREENING OF ANTIOXIDANTS AND OTHER COMPOUNDS FOR ANTIMUTAGENIC PROPERTIES TOWARDS BENZO[A]PYRENE-INDUCED MUTAGENICITY IN STRAIN TA98 OF SALMONELLA-TYPHIMURIUM [J].

CALLE, LM ;

SULLIVAN, PD .

MUTATION RESEARCH, 1982, 101 (02) :99-114

[4] EFFECT OF VITAMIN-E DIETARY-INTAKE ON IN-VITRO ACTIVATION OF AFLATOXIN-B1 [J].

CASSAND, P ;

DECOUDU, S ;

LEVEQUE, F ;

DAUBEZE, M ;

NARBONNE, JF .

MUTATION RESEARCH, 1993, 319 (04) :309-316

[5] LIPID-PEROXIDATION AND BENZO[A]PYRENE ACTIVATION TO MUTAGENIC METABOLITES - INVIVO INFLUENCE OF VITAMIN-A, VITAMIN-E AND VITAMIN-C AND GLUTATHIONE IN BOTH DIETARY VITAMIN-A SUFFICIENCY AND DEFICIENCY [J].

COLIN, C ;

NARBONNE, JF ;

MIGAUD, ML ;

GROLIER, P ;

CASSAND, P ;

PELLISSIER, MA .

MUTATION RESEARCH, 1991, 246 (01) :159-168

[6] VITAMIN-A AND GLUTATHIONE-MEDIATED FREE-RADICAL DAMAGE - COMPETING REACTIONS WITH POLY-UNSATURATED FATTY-ACIDS AND VITAMIN-C [J].

DAQUINO, M ;

DUNSTER, C ;

WILLSON, RL .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 161 (03) :1199-1203

[7] EFFECT OF VITAMIN-A DIETARY-INTAKE ON INVITRO AND INVIVO ACTIVATION OF AFLATOXIN-B1 [J].

DECOUDU, S ;

CASSAND, P ;

DAUBEZE, M ;

FRAYSSINET, C ;

NARBONNE, JF .

MUTATION RESEARCH, 1992, 269 (02) :269-278

[8] ANTIMUTAGENS AS CANCER CHEMOPREVENTIVE AGENTS IN THE DIET [J].

FERGUSON, LR .

MUTATION RESEARCH, 1994, 307 (01) :395-410

[9]

FIALA ES, 1977, CANCER, V40, P2436, DOI 10.1002/1097-0142(197711)40:5+<2436::AID-CNCR2820400908>3.0.CO

[10]

2-U

← 1 2 3 →