A Special Population of Regulatory T Cells Potentiates Muscle Repair

被引：917

作者：

Burzyn, Dalia ^{[1
]}

Kuswanto, Wilson ^{[1
]}

Kolodin, Dmitriy ^{[1
]}

Shadrach, Jennifer L. ^{[2
,3
]}

Cerletti, Massimiliano ^{[2
]}

Jang, Young ^{[2
]}

Sefik, Esen ^{[1
]}

Tan, Tze Guan ^{[1
]}

Wagers, Amy J. ^{[2
,3
]}

Benoist, Christophe ^{[1
]}

Mathis, Diane ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Boston, MA 02115 USA

[2] Harvard Univ, Cambridge, MA 02138 USA

[3] Howard Hughes Med Inst, Chevy Chase, MD 20815 USA

来源：

CELL | 2013年 / 155卷 / 06期

关键词：

GROWTH-FACTOR; UNIQUE POPULATION; SYSTEM; DIFFERENTIATION; AMPHIREGULIN; REGENERATION; CYTOKINE; SURVIVAL; SUBSETS; MICE;

D O I：

10.1016/j.cell.2013.10.054

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Long recognized to be potent suppressors of immune responses, Foxp3(+)CD4(+) regulatory T (Treg) cells are being rediscovered as regulators of nonimmunological processes. We describe a phenotypically and functionally distinct population of Treg cells that rapidly accumulated in the acutely injured skeletal muscle of mice, just as invading myeloid-lineage cells switched from a proinflammatory to a proregenerative state. A Treg population of similar phenotype accumulated in muscles of genetically dystrophic mice. Punctual depletion of Treg cells during the repair process prolonged the proinflammatory infiltrate and impaired muscle repair, while treatments that increased or decreased Treg activities diminished or enhanced (respectively) muscle damage in a dystrophy model. Muscle Treg cells expressed the growth factor Amphiregulin, which acted directly on muscle satellite cells in vitro and improved muscle repair in vivo. Thus, Treg cells and their products may provide new therapeutic opportunities for wound repair and muscular dystrophies.

引用

收藏

页码：1282 / 1295

页数：14

相关论文

共 30 条

[1] ErbB2 is required for muscle spindle and myoblast cell survival [J].

Andrechek, ER ;

Hardy, WR ;

Girgis-Gabardo, AA ;

Perry, RLS ;

Butler, R ;

Graham, FL ;

Kahn, RC ;

Rudnicki, MA ;

Muller, WJ .

MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (13) :4714-4722

[2] Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis [J].

Arnold, Ludovic ;

Henry, Adeline ;

Poron, Francoise ;

Baba-Amer, Yasmine ;

van Rooijen, Nico ;

Plonquet, Anne ;

Gherardi, Romain K. ;

Chazaud, Benedicte .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (05) :1057-1069

[3] Restricted islet-cell reactive T cell repertoire of early pancreatic islet infiltrates in NOD mice [J].

Baker, FJ ;

Lee, M ;

Chien, YH ;

Davis, MM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (14) :9374-9379

[4] DC ablation in mice: promises, pitfalls, and challenges [J].

Bennett, Clare L. ;

Clausen, Bjoern E. .

TRENDS IN IMMUNOLOGY, 2007, 28 (12) :525-531

[5] Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation [J].

Beyer, Marc ;

Thabet, Yasser ;

Mueller, Roman-Ulrich ;

Sadlon, Timothy ;

Classen, Sabine ;

Lahl, Katharina ;

Basu, Samik ;

Zhou, Xuyu ;

Bailey-Bucktrout, Samantha L. ;

Krebs, Wolfgang ;

Schoenfeld, Eva A. ;

Boettcher, Jan ;

Golovina, Tatiana ;

Mayer, Christian T. ;

Hofmann, Andrea ;

Sommer, Daniel ;

Debey-Pascher, Svenja ;

Endl, Elmar ;

Limmer, Andreas ;

Hippen, Keli L. ;

Blazar, Bruce R. ;

Balderas, Robert ;

Quast, Thomas ;

Waha, Andreas ;

Mayer, Guenter ;

Famulok, Michael ;

Knolle, Percy A. ;

Wickenhauser, Claudia ;

Kolanus, Waldemar ;

Schermer, Bernhard ;

Bluestone, Jeffrey A. ;

Barry, Simon C. ;

Sparwasser, Tim ;

Riley, James L. ;

Schultze, Joachim L. .

NATURE IMMUNOLOGY, 2011, 12 (09) :898-U125

[6] Macrophages in injured skeletal muscle: a perpetuum mobile causing and limiting fibrosis, prompting or restricting resolution and regeneration [J].

Bosurgi, Lidia ;

Manfredi, Angelo A. ;

Rovere-Querini, Patrizia .

FRONTIERS IN IMMUNOLOGY, 2011, 2

[7] Selective stimulation of T cell subsets with antibody-cytokine immune complexes [J].

Boyman, O ;

Kovar, M ;

Rubinstein, MP ;

Surh, CD ;

Sprent, J .

SCIENCE, 2006, 311 (5769) :1924-1927

[8] IMGT/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis [J].

Brochet, Xavier ;

Lefranc, Marie-Paule ;

Giudicelli, Veronique .

NUCLEIC ACIDS RESEARCH, 2008, 36 :W503-W508

[9] Short-Term Calorie Restriction Enhances Skeletal Muscle Stem Cell Function [J].

Cerletti, Massimiliano ;

Jang, Young C. ;

Finley, Lydia W. S. ;

Haigis, Marcia C. ;

Wagers, Amy J. .

CELL STEM CELL, 2012, 10 (05) :515-519

[10] PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells [J].

Cipolletta, Daniela ;

Feuerer, Markus ;

Li, Amy ;

Kamei, Nozomu ;

Lee, Jongsoon ;

Shoelson, Steven E. ;

Benoist, Christophe ;

Mathis, Diane .

NATURE, 2012, 486 (7404) :549-U151