Glycodendrimer synthesis without using protecting groups

被引:60
作者
Kieburg, C [1 ]
Lindhorst, TK [1 ]
机构
[1] UNIV HAMBURG,DEPT ORGAN CHEM,D-20146 HAMBURG,GERMANY
关键词
D O I
10.1016/S0040-4039(97)00760-0
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Oligoantennary neoglycoconjugates can act as powerful inhibitors of carbohydrate-protein interactions and thus serve as antiadhesives in carbohydrate-based adhesion systems. They were obtained by a procedure that doesn't require protecting groups. Various unprotected NCS-functionalized saccharides were coupled with oligoamines in aqueous solution. This versatile method is generally applicable to the synthesis of thiourea-bridged glycodendrimers. (C) 1997 Elsevier Science Ltd.
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页码:3885 / 3888
页数:4
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