Insight into the mechanism of direct catalytic aldol addition mediated by ambifunctional titanium complexes

被引：45

作者：

Mahrwald, R ^{[1
]}

Ziemer, B ^{[1
]}

机构：

[1] Humboldt Univ, Inst Organ & Bioorgan Chem, D-12489 Berlin, Germany

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 25期

关键词：

aldol addition; enantioselectivity; catalysis; titanium complexes;

D O I：

10.1016/S0040-4039(02)00822-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

X-Ray structure analysis of a titanium(IV) isopropoxide/mandelic acid complex provides an insight into the mechanism of this novel direct enantioselective aldol addition. The catalytic cycle mediated by the titanium(IV) alkoxide/mandelic acid complex is presented. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：4459 / 4461

页数：3

共 19 条

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