Evidence for T-large granular lymphocyte-mediated neutropenia in Rituximab-treated lymphoma patients: report of two cases

被引：64

作者：

Papadaki, T

Stamatopoulos, K

Stavroyianni, N

Paterakis, G

Phisphis, M

Stefanoudaki-Sofianatou, K

机构：

[1] Evangelismos Med Ctr, Hemopathol Unit, Athens, Greece

[2] Univ Athens, Sch Med, Dept Med 1, GR-11527 Athens, Greece

[3] G Gennimatas Hosp, Immunol Lab, Athens, Greece

[4] Amalia Fleming Hosp, Dept Hematol, Athens, Greece

来源：

LEUKEMIA RESEARCH | 2002年 / 26卷 / 06期

关键词：

lymphoma; Rituximab; neutropenia; T-LGL;

D O I：

10.1016/S0145-2126(01)00183-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report two cases with B cell malignancies (case #1: refractory mantle cell lymphoma; case #2: lymphocyte predominant Hodgkin's disease (LPHD)) who developed neutropenia post-Rituximab therapy in a setting of significant infiltration of the peripheral blood (PB) and bone marrow (BM) by T cells with an immunophenotype of large granular lymphocytes. Possible pathogenetic mechanisms are discussed. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：597 / 600

页数：4

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