Calbindin D-28k, Parvalbumin and Calcitonin Gene-Related Peptide Immunoreactivity in the Canine Spinal Cord

被引：12

作者：

Chang, I. Y. ^{[3
]}

Kim, S. W. ^{[2
]}

Lee, K. J. ^{[4
]}

Yoon, S. P. ^{[1
,3
,5
]}

机构：

[1] Chosun Univ, Dept Anat, Kwangju 501759, South Korea

[2] Chosun Univ, Dept Neurosurg, Coll Med, Kwangju 501759, South Korea

[3] Chosun Univ, Korea DNA Repair Res Ctr, Kwangju 501759, South Korea

[4] Hanlyo Univ, Grad Sch Ind, Gwangyang 545704, Jeollanam Do, South Korea

[5] Seonam Univ, Dept Anat, Coll Med, Namwon 590711, Jeollabuk Do, South Korea

来源：

ANATOMIA HISTOLOGIA EMBRYOLOGIA | 2008年 / 37卷 / 06期

关键词：

D O I：

10.1111/j.1439-0264.2008.00879.x

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 [人体解剖与组织胚胎学];

摘要：

This study was conducted as a comparative analysis of the immunohistochemical localization of calbindin D-28k, parvalbumin and the calcitonin gene-related peptide (CGRP) in the cervical through the sacral spinal cord of mongrel dogs, to reveal any distinct patterns of distribution and possible involvement in spinal processing. In laminae I and II of the substantia gelatinosa, both calbindin D-28k and CGRP showed strong immunoreactivity, with calbindin D-28k being positive in both cells and fibres, while CGRP was positive in fibres only. Parvalbumin and CGRP immunoreactive cells were widely distributed in various nuclei and lower motor neurones in the ventromedial horn. In addition, the lower motor neurones expressed CGRP as well as parvalbumin, but not calbindin D-28k. These results are generally consistent with previous reports, and the co-localization of parvalbumin and CGRP may explain the functional improvement of lower motor neuron disease.

引用

页码：446 / 451

页数：6

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