Antioxidant activity of N-carboxymethyl chitosan oligosaccharides

被引：102

作者：

Sun, Tao ^{[1
]}

Yao, Qian ^{[1
]}

Zhou, Dongxiang ^{[1
]}

Mao, Fang ^{[1
]}

机构：

[1] Shanghai Ocean Univ, Coll Food Sci, Shanghai 200090, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 21期

关键词：

Chitosan oligosaccharide; Carboxymethyl chitosan oligosaccharide; Substituting degree; Antioxidant activity; Reducing power;

D O I：

10.1016/j.bmcl.2008.09.072

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three N-carboxymethyl chitosan oligosaccharides (N-CMCOSs) with different degrees of substitution (NA: 0.28, NB: 0.41, and NC: 0.54, respectively) were prepared by the control of the amount of glyoxylic acid in the etherification process of chitosan oligosaccharide (COS). Their antioxidant activities were evaluated by the scavenging of 1,1-diphenyl-2-picrylhrazyl radical (DPPH) radical, superoxide anion and determination of reducing power. With the increasing of substituting degree, the scavenging activity of N-CMCOSs against DPPH radical decreased and reducing power increased. As for superoxide anion scavenging, the order is NB > NC > NA. The difference may be related to the different radical scavenging mechanisms and donating effect of substituting carboxymethyl group. (C) 2008 Published by Elsevier Ltd.

引用

页码：5774 / 5776

页数：3

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