Novel 7-hydroxycoumarin based fluorescent labels

被引：40

作者：

Adamczyk, M

Cornwell, M

Huff, J

Rege, S

Rao, TVS

机构：

[1] Abbott Laboratories, Diagnostics Division, D9NM/AP20, Abbott Park, IL 60064

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 15期

关键词：

D O I：

10.1016/S0960-894X(97)00345-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Five new 7-hydroxy-8-(N-alkylaminomethyl)coumarin labels (6a-e) were prepared from 4-(4-carboxybutyl)-7-hydroxycoumarin (4) in 28-48% yield. Compared to 4-methylumbelliferone (4-MU, 1), the new fluorescent labels exhibited higher emission intensity over a broader pH range. Extinction coefficients, quantum yields and pKa values are also reported for these labels. (C) 1997 Elsevier Science Ltd.

引用

页码：1985 / 1988

页数：4

共 23 条

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