Anti-inflammatory of pyrrolizidine alkaloids from Heliotropium digynum

被引：12

作者：

Aboelmagd, Mohamed ^{[1
,2
]}

Elokely, Khaled ^{[3
,4
,5
]}

Zaki, Mohamed A. ^{[6
]}

Said, Ataa ^{[2
]}

Haggag, Eman G. ^{[7
]}

Ross, Samir A. ^{[1
,8
]}

机构：

[1] Univ Mississippi, Natl Ctr Nat Prod Res, Sch Pharm, University, MS 38677 USA

[2] Natl Res Ctr, Dept Pharmacognosy, Giza 12622, Egypt

[3] Temple Univ, Dept Chem, Philadelphia, PA 19122 USA

[4] Temple Univ, Inst Computat Mol Sci, Philadelphia, PA 19122 USA

[5] Tanta Univ, Dept Pharmaceut Chem, Tanta 31527, Egypt

[6] Beni Suef Univ, Dept Pharmacognosy, Fac Pharm, Bani Suwayf, Egypt

[7] Helwan Univ, Dept Pharmacognosy, Fac Pharm, Cairo 11795, Egypt

[8] Univ Mississippi, Sch Pharm, Pharmacognosy Div, Dept BioMol Sci, University, MS 38677 USA

来源：

MEDICINAL CHEMISTRY RESEARCH | 2018年 / 27卷 / 04期

关键词：

Heliotropium digynum; New pyrrolizidine alkaloid; Anti-inflammatory; Docking; ACCURATE DOCKING; PROTEIN; GLIDE; SUBULATUM; FISCH; MEY;

D O I：

10.1007/s00044-017-2128-y

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

One new and six known pyrrolizidine alkaloids (1-7) were isolated from the 70% ethanol extract of the aerial parts of Heliotropium digynum (Forssk.) C. Chr. The chemical structure of the new compound, 7-Angeloylsincamidine N-Oxide (4) was determined by extensive 1D and 2D NMR spectroscopic analysis and HRESIMS. The absolute configuration of 4 was elucidated by comparing the experimental and electronic circular dichroism spectra. The anti-inflammatory activity of the ethanolic extract and compounds 1, 2, 4, and 6 were evaluated against the Nitric oxide production in lipopolysaccharide induced murine macrophages RAW 264.7 cells. The IC50 values of the tested compounds were 52.4, 85.1, 105.1, and 7.9 A mu M, respectively, while the % inhibition of the ethanolic extract at 25 A mu g/mL was 78.7%. A docking study was conducted to provide more explanation about the activity of the tested compounds.

引用

页码：1066 / 1073

页数：8

共 32 条

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