Mechanisms of regulated unconventional protein secretion

被引：542

作者：

Nickel, Walter ^{[1
]}

Rabouille, Catherine ^{[2
]}

机构：

[1] Heidelberg Univ, Biochem Ctr, D-69120 Heidelberg, Germany

[2] UMC Utrecht, Dept Cell Biol, Cell Microscopy Ctr, NL-3584 CX Utrecht, Netherlands

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2009年 / 10卷 / 02期

基金：

欧洲研究理事会;

关键词：

TRANSMEMBRANE CONDUCTANCE REGULATOR; ENDOPLASMIC-RETICULUM EXIT; NALP3; INFLAMMASOME; CELL-SURFACE; HEPARAN-SULFATE; PLASMA-MEMBRANE; TERMINAL DIFFERENTIATION; ESSENTIAL COMPONENTS; IL-1-BETA SECRETION; EXPORT MACHINERY;

D O I：

10.1038/nrm2617

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Most eukaryotic proteins are secreted through the conventional endoplasmic reticulum (ER)-Golgi secretory pathway. However, cytoplasmic, nuclear and signal-peptide- containing proteins have been shown to reach the cell surface by non-conventional transport pathways. the mechanisms and molecular components of unconventional protein secretion are beginning to emerge, including a role for caspase 1 and for the peripheral Golgi protein GRASP, which could function as a plasma membrane tether for membrane compartments during specific stages of development.

引用

页码：148 / 155

页数：9

共 93 条

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