Perospirone in the treatment of schizophrenia: Effect on verbal memory organization

被引：23

作者：

Araki, T

Yamasue, H

Sumiyoshi, T

Kuwabara, H

Suga, M

Iwanami, A

Kato, N

Kasai, K

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Neuropsychiat, Bunkyo Ku, Tokyo 1138655, Japan

[2] Toyama Univ, Sch Med, Dept Neuropsychiat, Toyama 9300194, Japan

[3] Kaijoryo Hosp, Asahi, Chiba 2892513, Japan

[4] Tokyo Metropolitan Matsuzawa Hosp, Setagaya Ku, Tokyo 1560057, Japan

[5] Tokyo Metropolitan Bokuto Gen Hosp, Sumida Ku, Tokyo 1308575, Japan

[6] Aino Univ, Dept Med Technol, Ibaraki, Osaka 5670018, Japan

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2006年 / 30卷 / 02期

基金：

日本学术振兴会;

关键词：

atypical antipsychotics; cognitive function; memory organization; perospirone; schizophrenia; 5-HT1A receptors;

D O I：

10.1016/j.pnpbp.2005.10.015

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The present study was performed to determine if perospirone, a novel antipsychotic drug with D-2/5-HT2A antagonist and partial 5-HT1A agonist properties, would improve memory organization in twelve patients with chronic schizophrenia. Switching to equivalent dose of perospirone from prior antipsychotic medication was associated with a significant improvement in indices of verbal memory organization of the Auditory Verbal Learning Test. Negative symptoms and extrapyramidal side effects were also ameliorated after switching to perospirone. The distinct cognitive enhancement profile of perospirone may be attributable to its partial 5-HT1A agonist action. (C) 2005 Elsevier Inc. All rights reserved.

引用

页码：204 / 208

页数：5

共 49 条

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