The SRC family protein tyrosine kinase p62yes controls polymeric IgA transcytosis in vivo

被引：72

作者：

Luton, F

Vergés, M

Vaerman, JP

Sudol, M

Mostov, KE ^{[1
]}

机构：

[1] Univ Calif San Francisco, Inst Cardiovasc Res, Dept Anat, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Inst Cardiovasc Res, Dept Biochem, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Inst Cardiovasc Res, Dept Biophys, San Francisco, CA 94143 USA

[4] Univ Catholique Louvain, Christian Duve Inst Cellular Pathol, Unit Expt Med, B-1200 Brussels, Belgium

[5] CUNY Mt Sinai Sch Med, Dept Biochem, New York, NY 10029 USA

来源：

MOLECULAR CELL | 1999年 / 4卷 / 04期

关键词：

D O I：

10.1016/S1097-2765(00)80213-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transcytosis of polymeric immunoglobulin A (pIgA) across epithelial cells is mediated by the polymeric immunoglobulin receptor (pIgR). Binding of pIgA to pIgR stimulates transcytosis of the pIgA-pIgR complex via a signal transduction pathway that is dependent on a protein tyrosine kinase (PTK) of the SRC family. Here we identify the PTK as p62(yes). We demonstrate the specific physical and functional association of the pIgR with p62(yes) in rodent liver. Analysis of p62(yes) knockout mice revealed a dramatic reduction in the association of tyrosine kinase activity with the pIgR and in transcytosis of pIgA. We conclude that p62(yes) controls pIgA transcytosis in vivo.

引用

页码：627 / 632

页数：6

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