Delineating the cellular pathways of hematopoietic lineage commitment

被引：37

作者：

Luc, Sidinh ^{[1
,2
]}

Buza-Vidas, Natalija ^{[1
]}

Jacobsen, Sten Eirik W. ^{[1
,2
]}

机构：

[1] Univ Oxford, John Radcliffe Hosp, Weatherall Inst Mol Med, Haematopoiet Stem Cell Lab, Oxford OX3 9DS, England

[2] Lund Univ, Hematopoiet Stem Cell Lab, Lund Strateg Res Ctr Stem Cell Biol & Cell Therap, S-22184 Lund, Sweden

来源：

SEMINARS IN IMMUNOLOGY | 2008年 / 20卷 / 04期

基金：

英国医学研究理事会;

关键词：

hematopoietic stem cells; lineage commitment; lymphoid-primed multipotent progenitors; fetal; transcriptional priming;

D O I：

10.1016/j.smim.2008.07.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The prevailing model for adult hematopoiesis postulates that the first lineage commitment step results in a strict separation of common myeloid and common lymphoid pathways. However, the recent identification of granulocyte/monocyte (GM)-lymphoid restricted lymphoid-primed multipotent progenitors (LMPPs) and primitive common myeloid progenitors (CMPs) within the "HSC" compartment provide compelling support for establishment of independent GM-megakaryocyte/erythroid (GM-MkE) and GM-lymphoid commitment pathways as decisive early lineage fate decisions. These changes in lineage potentials are corroborated by corresponding changes in multilineage transcriptional priming, as LMPPs down-regulate MkE priming but become GM-lymphoid transcriptionally primed, whereas CMPs are GM-MkE primed. These distinct biological and molecular relationships are established already in the fetal liver. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：213 / 220

页数：8

共 49 条

[1] Upregulation of flt3 expression within the bone marrow Lin-Sca1+c-kit+ stem cell compartment is accompanied by loss of self-renewal capacity [J].