Pathophysiology of Osteoporosis New Mechanistic Insights

被引：348

作者：

Armas, Laura A. G. ^{[1
]}

Recker, Robert R. ^{[1
]}

机构：

[1] Creighton Univ, Med Ctr, Dept Internal Med, Osteoporosis Res Ctr,Endocrine Div, Omaha, NE 68131 USA

来源：

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2012年 / 41卷 / 03期

关键词：

Osteoporosis; Remodeling; Bone quality; Mechanical loading; Microdamage; BONE-MINERAL DENSITY; LONG-TERM IMMOBILIZATION; VERTEBRAL FRACTURE RISK; MICRODAMAGE ACCUMULATION; POSTMENOPAUSAL WOMEN; TRABECULAR BONE; ESTROGEN DEFICIENCY; STRESS-FRACTURES; COMPACT-BONE; BED REST;

D O I：

10.1016/j.ecl.2012.04.006

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Understanding of the pathophysiology of osteoporosis has evolved to include compromised bone strength and skeletal fragility caused by several factors: (1) defects in microarchitecture of trabeculae, (2) defective intrinsic material properties of bone tissue, (3) defective repair of microdamage from normal daily activities, and (4) excessive bone remodeling rates. These factors occur in the context of age-related bone loss. Clinical studies of estrogen deprivation, antiresorptives, mechanical loading, and disuse have helped further knowledge of the factors affecting bone quality and the mechanisms that underlie them. This progress has led to several new drug targets in the treatment of osteoporosis.

引用

页码：475 / +

页数：13

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