Identification of dioxin-responsive elements (DREs) in the 5'regions of putative dioxin-inducible genes

被引：82

作者：

Lai, ZW

Pineau, T

Esser, C

机构：

[1] UNIV DUSSELDORF,INST ENVIRONM HYG,D-40225 DUSSELDORF,GERMANY

[2] INRA,LAB PHARMACOL TOXICOL,F-31931 TOULOUSE,FRANCE

来源：

CHEMICO-BIOLOGICAL INTERACTIONS | 1996年 / 100卷 / 02期

关键词：

Ah receptor; 2,3,7,8-tetrachlorodibenzo-p-dioxin; dioxin responsive elements;

D O I：

10.1016/0009-2797(96)03691-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is an exogenous ligand for the cytosolic aryl hydrocarbon receptor (AhR), a ligand-inducible transcription factor whose exact physiological role remains elusive. TCDD has been shown to modulate the expression of a large array of genes, albeit often indirectly, by demonstration of protein or mRNA upregulation. Here, by computer analysis of available promoter sequences, we identify dioxin-responsive elements in the promoter regions of many putative AhR regulated and therefore dioxin-inducible genes.

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页码：97 / 112

页数：16

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