Distribution of the HLA-A9 antigen family (A23, A24 and A2403)

被引：10

作者：

Thomas, M ^{[1
]}

Street, J ^{[1
]}

Fussell, H ^{[1
]}

Guttridge, M ^{[1
]}

Darke, C ^{[1
]}

机构：

[1] NATL BLOOD TRANSFUS SERV WALES, REG TISSUE TYPING LAB, CARDIFF CF5 6XF, S GLAM, WALES

来源：

TISSUE ANTIGENS | 1996年 / 48卷 / 05期

关键词：

antigen allele frequencies; bone marrow donors; Hardy-Weinberg equilibrium; HLA-A23; HLA-A24; HLA-A2403; linkage disequilibrium; PCR-SSP;

D O I：

10.1111/j.1399-0039.1996.tb02673.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Characterization of 50 local anti-HLA-A9 (A23 and/or A24) sera against the HLA-A2403 antigen allowed the retrospective assignment of A2403 and the verification of A23 and A24 specificities in a panel of 9196 volunteer bone marrow donors. The six A2403 positive subjects identified were confirmed by PCR using four sequence-specific primer mixtures. Population analysis showed the distribution and HLA-A/B linkage disequilibrium of HLA-A23 and A24 to be typical of a Northern European Caucasoid population. HLA-A2403 has a phenotype frequency of 0.00065 (gene frequency - 0.00033) and is in linkage disequilibrium with HLA-B63 and possibly B35.

引用

页码：586 / 588

页数：3

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