Fish oil regulates adiponectin secretion by a peroxisome proliferator-activated receptor-γ-dependent mechanism in mice

被引:222
作者
Neschen, S
Morino, K
Rossbacher, JC
Pongratz, RL
Cline, GW
Sono, S
Gillum, M
Shulman, GI
机构
[1] Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06536 USA
[2] Yale Univ, Sch Med, Dept Internal Med, New Haven, CT 06536 USA
[3] Yale Univ, Sch Med, Dept Cellular & Mol Physiol, New Haven, CT 06536 USA
[4] Yale Univ, Sch Med, Dept Lab Med, New Haven, CT 06536 USA
关键词
D O I
10.2337/diabetes.55.04.06.db05-0985
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Adiponectin has insulin-sensitizing, antiatherogenic, and anti-inflammatory properties, but little is known about factors that regulate its secretion. To examine the effect of fish oil on adiponectin secretion, mice were fed either a control diet or isocaloric diets containing 27% safflower oil or 27, 13.5, and 8% menhaden fish oil. Within 15 days, fish oil feeding raised plasma adiponectin concentrations two-to threefold in a dose-dependent manner, and the concentrations remained approximately twofold higher for 7 days when the fish oil diet was replaced by the safflower oil diet. Within 24 It, fish oil markedly induced transcription of the adiponectin gene in epididymal adipose tissue but not in subcutaneous fat. The increase of plasma adiponectin by fish oil was completely blocked by administration of the peroxisome proliferator-activated receptor (PPAR)gamma inhibitor bisphenol-A-diglycidyl ether. In contrast, there was no effect of fish oil feeding on adiponectin secretion in PPAR alpha-null mice. These data suggest that fish oil is a naturally occurring potent regulator of adiponectin secretion in vivo and that it does so through a PPAR-gamma-dependent and PPAR alpha-independent manner in epididymal fat.
引用
收藏
页码:924 / 928
页数:5
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