MEK Wars, a new front in the battle against cancer

被引：34

作者：

Duesbery, NS

Webb, CP

Woude, GFV ^{[1
]}

机构：

[1] NCI, Div Basic Sci, Bethesda, MD 20892 USA

[2] NCI, Frederick Canc Res & Dev Ctr, ABL Basic Res Program, Frederick, MD 21702 USA

[3] Van Andel Rsch Inst, Grand Rapids, MI 49503 USA

来源：

NATURE MEDICINE | 1999年 / 5卷 / 07期

关键词：

D O I：

10.1038/10457

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A specific inhibitor of the mitogen-activated protein kinase (MAPK or ERK) pathway is introduced as a new member in the growing search for cytostatic drugs that block tumor growth (pages 810–816).

引用

页码：736 / 737

页数：2

共 14 条

[1] ACTIVATION OF MAP KINASE KINASE IS NECESSARY AND SUFFICIENT FOR PC12 DIFFERENTIATION AND FOR TRANSFORMATION OF NIH 3T3 CELLS
COWLEY, S
PATERSON, H
KEMP, P
MARSHALL, CJ
[J]. CELL, 1994, 77 (06) : 841 - 852
[2] A SYNTHETIC INHIBITOR OF THE MITOGEN-ACTIVATED PROTEIN-KINASE CASCADE
DUDLEY, DT
PANG, L
DECKER, SJ
BRIDGES, AJ
SALTIEL, AR
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (17) : 7686 - 7689
[3] DUESBERY N, 1999, IN PRESS APPL MICROB
[4] Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor
Duesbery, NS
Webb, CP
Leppla, SH
Gordon, VM
Klimpel, KR
Copeland, TD
Ahn, NG
Oskarsson, MK
Fukasawa, K
Paull, KD
Vande Woude, GF
[J]. SCIENCE, 1998, 280 (5364) : 734 - 737
[5] Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors
Hoshino, R
Chatani, Y
Yamori, T
Tsuruo, T
Oka, H
Yoshida, O
Shimada, Y
Ari-i, S
Wada, H
Fujimoto, J
Kohno, M
[J]. ONCOGENE, 1999, 18 (03) : 813 - 822
[6] Signal transduction through MAP kinase cascades
Lewis, TS
Shapiro, PS
Ahn, NG
[J]. ADVANCES IN CANCER RESEARCH, VOL 74, 1998, 74 : 49 - 139
[7] In situ visualization of intratumor growth factor signaling -: Immunohistochemical localization of activated ERK/MAP kinase in glial neoplasms
Mandell, JW
Hussaini, IM
Zecevic, M
Weber, MJ
VandenBerg, SR
[J]. AMERICAN JOURNAL OF PATHOLOGY, 1998, 153 (05) : 1411 - 1423
[8] TRANSFORMATION OF MAMMALIAN-CELLS BY CONSTITUTIVELY ACTIVE MAP KINASE KINASE
MANSOUR, SJ
MATTEN, WT
HERMANN, AS
CANDIA, JM
RONG, S
FUKASAWA, K
VANDEWOUDE, GF
AHN, NG
[J]. SCIENCE, 1994, 265 (5174) : 966 - 970
[9] Nishio K, 1999, INT J ONCOL, V14, P461
[10] OKAZAKI K, 1995, ONCOGENE, V10, P1149

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