DNA viruses and the cellular DNA-damage response

被引:118
作者
Turnell, Andrew S. [1 ]
Grand, Roger J. [1 ]
机构
[1] Univ Birmingham, Sch Canc Sci, Coll Med & Dent Sci, Birmingham B15 2TT, W Midlands, England
关键词
HERPES-SIMPLEX-VIRUS; HUMAN-PAPILLOMAVIRUS TYPE-16; PROTEASOME-DEPENDENT DEGRADATION; LARGE T-ANTIGEN; REPLICATION PROTEIN-A; E3 UBIQUITIN LIGASE; CHECKPOINT SIGNAL-TRANSDUCTION; STRAND BREAK REPAIR; S-PHASE PROGRESSION; ADENOVIRUS E4 34K;
D O I
10.1099/vir.0.044412-0
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
It is clear that a number of host-cell factors facilitate virus replication and, conversely, a number of other factors possess inherent antiviral activity. Research, particularly over the last decade or so, has revealed that there is a complex inter-relationship between viral infection and the host-cell DNA-damage response and repair pathways. There is now a realization that viruses can selectively activate and/or repress specific components of these host-cell pathways in a temporally coordinated manner, in order to promote virus replication. Thus, some viruses, such as simian virus 40, require active DNA-repair pathways for optimal virus replication, whereas others, such as adenovirus, go to considerable lengths to inactivate some pathways. Although there is ever-increasing molecular insight into how viruses interact with host-cell damage pathways, the precise molecular roles of these pathways in virus life cycles is not well understood. The object of this review is to consider how DNA viruses have evolved to manage the function of three principal DNA damage-response pathways controlled by the three phosphoinositide 3-kinase (PI3K)-related protein kinases ATM, ATR and DNA-PK and to explore further how virus interactions with these pathways promote virus replication.
引用
收藏
页码:2076 / 2097
页数:22
相关论文
共 209 条
[1]   Cu17/p185/p193 binding to simian virus 40 large T antigen has a role in cellular transformation [J].
Ali, SH ;
Kasper, JS ;
Arai, T ;
DeCaprio, JA .
JOURNAL OF VIROLOGY, 2004, 78 (06) :2749-2757
[2]   Adenovirus type 5 E4orf3 protein targets the Mre11 complex to cytoplasmic aggresomes [J].
Araujo, FD ;
Stracker, TH ;
Carson, CT ;
Lee, DV ;
Weitzman, MD .
JOURNAL OF VIROLOGY, 2005, 79 (17) :11382-11391
[3]   Functional Interaction between Epstein-Barr Virus Replication Protein Zta and Host DNA Damage Response Protein 53BP1 [J].
Bailey, Sarah G. ;
Verrall, Elizabeth ;
Schelcher, Celine ;
Rhie, Alex ;
Doherty, Aidan J. ;
Sinclair, Alison J. .
JOURNAL OF VIROLOGY, 2009, 83 (21) :11116-11122
[4]   Adenovirus E4 34k and E1b 55k oncoproteins target host DNA ligase IV for proteasomal degradation [J].
Baker, Amy ;
Rohleder, Kent J. ;
Hanakahi, Les A. ;
Ketner, Gary .
JOURNAL OF VIROLOGY, 2007, 81 (13) :7034-7040
[5]   Physical Interaction between the Herpes Simplex Virus Type 1 Exonuclease, UL12, and the DNA Double-Strand Break-Sensing MRN Complex [J].
Balasubramanian, Nandakumar ;
Bai, Ping ;
Buchek, Gregory ;
Korza, George ;
Weller, Sandra K. .
JOURNAL OF VIROLOGY, 2010, 84 (24) :12504-12514
[6]   Human Papillomavirus (HPV) E7 Induces Prolonged G2 following S Phase Reentry in Differentiated Human Keratinocytes [J].
Banerjee, N. Sanjib ;
Wang, Hsu-Kun ;
Broker, Thomas R. ;
Chow, Louise T. .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (17) :15473-15482
[7]   Hepatitis B virus X protein interferes with cellular DNA repair [J].
Becker, SA ;
Lee, TH ;
Butel, JS ;
Slagle, BL .
JOURNAL OF VIROLOGY, 1998, 72 (01) :266-272
[8]   Turnover of hepatitis B virus X protein is regulated by damaged DNA-binding complex [J].
Bergametti, F ;
Sitterlin, D ;
Transy, C .
JOURNAL OF VIROLOGY, 2002, 76 (13) :6495-6501
[9]   Recent lessons in gene expression, cell cycle control, and cell biology from adenovirus [J].
Berk, AJ .
ONCOGENE, 2005, 24 (52) :7673-7685
[10]   How adeno-associated virus Rep78 protein arrests cells completely in S phase [J].
Berthet, C ;
Raj, K ;
Saudan, P ;
Beard, P .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (38) :13634-13639