Identity by Descent Between Distant Relatives: Detection and Applications

被引：127

作者：

Browning, Sharon R. ^{[1
]}

Browning, Brian L. ^{[2
]}

机构：

[1] Univ Washington, Dept Stat, Seattle, WA 98195 USA

[2] Univ Washington, Dept Med, Div Med Genet, Seattle, WA 98195 USA

来源：

ANNUAL REVIEW OF GENETICS, VOL 46 | 2012年 / 46卷

关键词：

cryptic relatedness; coancestry; IBD mapping; haplotype phase inference; effective population size; WHOLE-GENOME ASSOCIATION; GRAY PLATELET SYNDROME; LINKAGE ANALYSIS; BY-DESCENT; MISSING HERITABILITY; POPULATION-STRUCTURE; NATURAL-SELECTION; IDENTIFICATION; INFERENCE; REGIONS;

D O I：

10.1146/annurev-genet-110711-155534

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Short segments of identity by descent (IBD) between individuals with no known relationship can be detected using genome-wide single nucleotide polymorphism data and recently developed statistical methodology. Emerging applications for the detected IBD segments include IBD mapping, haplotype phase inference, genotype imputation, and inference of population structure. In this review, we explain the principles behind methods for IBD segment detection, describe recently developed methods, discuss approaches to comparing methods, and give an overview of applications.

引用

页码：617 / 633

页数：17

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