A human monoclonal antibody which inhibits the coaggregation activity of Porphyromonas gingivalis

被引：29

作者：

Abiko, Y

Ogura, N

Matsuda, U

Yanagi, K

Takiguchi, H

机构：

[1] NIHON UNIV,SCH DENT,DEPT ORAL SURG,MATSUDO,CHIBA 271,JAPAN

[2] NATL INST HLTH,TOKYO 164,JAPAN

来源：

INFECTION AND IMMUNITY | 1997年 / 65卷 / 09期

关键词：

D O I：

10.1128/IAI.65.9.3966-3969.1997

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A B-cell line producing a human monoclonal antibody (HuMAb) against a recombinant 40-kDa outer membrane protein (OMP) of Porphyromonas gingivalis was constructed by in vivo immunization of a severe combined immunodeficiency C.B.-17/Icr mouse, which had been injected with human peripheral blood lymphocytes, with recombinant 40-kDa OMP and subsequent Epstein-Barr virus immortalization of B cells isolated from the spleen of the mouse. This HuMAb inhibited coaggregation between P. gingivalis vesicles and Actinomyces naeslundii cells.

引用

页码：3966 / 3969

页数：4

共 28 条

[1] THE INHIBITORY MONOCLONAL-ANTIBODY M7-PB-E9 STABILIZES E(2) CONFORMATIONAL STATES OF NA+,K+-ATPASE [J].