Resolution of albuterol acetonide

被引：24

作者：

Caira, MR ^{[1
]}

Hunter, R ^{[1
]}

Nassimbeni, LR ^{[1
]}

Stevens, AT ^{[1
]}

机构：

[1] Univ Cape Town, Dept Chem, ZA-7701 Rondebosch, South Africa

来源：

TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 11期

关键词：

D O I：

10.1016/S0957-4166(99)00209-8

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The (R)-enantiomer of albuterol has been isolated via resolution of albuterol acetonide with (2S,3S)-di-O-benzoyl- or (2S,3S)-di-O-toluoyltartaric acid. The absolute configuration of the resolved acetonide was assessed by H-1 NMR analysis of its (R)-Mosher's ester, and confirmed by an X-ray crystal structure determination of the (R)-phenylethylurea derivative of the (S)-enantiomer. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2175 / 2189

页数：15

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