Linkage of proximal myotonic myopathy to chromosome 3q

被引：66

作者：

Ricker, K

Grimm, T

Koch, MC

Schneider, C

Kress, W

Reimers, CD

Schulte-Mattler, W

Mueller-Myhsok, B

Toyka, KV

Mueller, CR

机构：

[1] Univ Wurzburg, Dept Neurol, D-97070 Wurzburg, Germany

[2] Univ Wurzburg, Dept Human Genet, D-97070 Wurzburg, Germany

[3] Univ Marburg, Dept Human Genet, D-35032 Marburg, Germany

[4] Univ Gottingen, Dept Clin Neurophysiol, D-3400 Gottingen, Germany

[5] Univ Halle, Dept Neurol, Halle, Germany

[6] Bernhard Nocht Inst Trop Med, Hamburg, Germany

来源：

NEUROLOGY | 1999年 / 52卷 / 01期

关键词：

D O I：

10.1212/WNL.52.1.170

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We performed genetic linkage analysis in nine German proximal myotonic myopathy (PROMM) families using DNA-markers D3S1541 and D3S1589 from the region of the recently discovered gene locus of myotonic dystrophy type 2 (DM2) on chromosome 3q. Two-point analysis supplied an lod score of 5.9. We conclude that a gene causing PROMM is located on chromosome 3q. PROMM and DM2 may be allelic disorders or may be caused by closely linked genes.

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页码：170 / 171

页数：2

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