Holographic microrheology of polysaccharides from Streptococcus mutans biofilms

被引：45

作者：

Cheong, Fook Chiong ^{[1
,2
]}

Duarte, Simone ^{[3
]}

Lee, Sang-Hyuk ^{[4
]}

Grier, David G. ^{[1
,2
]}

机构：

[1] NYU, Dept Phys, New York, NY 10003 USA

[2] New York Univ, Ctr Soft Matter Res, New York, NY 10003 USA

[3] NYU, Coll Dent, Dept Basic Sci & Craniofacial Biol, New York, NY 10010 USA

[4] Univ Calif Berkeley, Dept Phys, Berkeley, CA 94720 USA

来源：

RHEOLOGICA ACTA | 2009年 / 48卷 / 01期

基金：

美国国家科学基金会;

关键词：

Video holographic microscopy; Microrheology; Biofilms; Polysaccharide gel; Streptococcus mutans; PARTICLE TRACKING MICRORHEOLOGY; COMPLEX FLUIDS; VISCOELASTIC MODULI; MICROBIAL BIOFILMS; SOFT MATERIALS; MICROSCOPY; FLUCTUATIONS; RHEOLOGY; DEVICE; SHEAR;

D O I：

10.1007/s00397-008-0320-1

中图分类号：

O3 [力学];

学科分类号：

08 ; 0801 ;

摘要：

We use three-dimensional holographic particle tracking to perform microrheological measurements of model gelled media, including the polysaccharide pellicle of dental biofilms created by the common cariogenic oral pathogen Streptococcus mutans. Nanometer-resolution video-rate holographic tracking of embedded colloidal spheres provides accurate measurements of the gels' complex viscoelastic moduli, including insights into these properties' heterogeneity. When applied to polysaccharides of S. mutans biofilms, these techniques promise quantitative microscopic assays for candidate therapeutic agents against cariogenic dental biofilms.

引用

页码：109 / 115

页数：7

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