Correlation between serum high-mobility group box-1 levels and high-sensitivity C-reactive protein and troponin I in patients with coronary artery disease

被引：29

作者：

Yao, Heng-Chen ^{[1
]}

Zhao, Ai-Ping ^{[1
]}

Han, Qian-Feng ^{[1
]}

Wu, Lei ^{[1
]}

Yao, Dao-Kuo ^{[2
]}

Wang, Le-Xin ^{[1
,3
]}

机构：

[1] Taishan Med Univ, Liaocheng Peoples Hosp, Dept Cardiol, Liaocheng 252000, Shandong, Peoples R China

[2] China Capital Med Univ, Beijing Friendship Hosp, Dept Cardiol, Beijing 100007, Peoples R China

[3] Charles Sturt Univ, Sch Biomed Sci, Wagga Wagga, NSW 2678, Australia

来源：

EXPERIMENTAL AND THERAPEUTIC MEDICINE | 2013年 / 6卷 / 01期

关键词：

coronary artery disease; high-mobility group box-1; high-sensitivity C-reactive protein; cardiac troponin I; MYOCARDIAL-INFARCTION; INFLAMMATION; ATHEROSCLEROSIS; GUIDELINES; MANAGEMENT; ACTIVATION; MORTALITY; ANGINA; HMGB1;

D O I：

10.3892/etm.2013.1095

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

The aim of this study was to evaluate the correlation between levels of serum high-mobility group box-1 (HMGB1) and high-sensitivity C-reactive protein (hs-CRP) and cardiac troponin I in patients with coronary artery disease. The levels of serum HMGB1, hs-CRP and cardiac troponin I were measured in 98 patients with coronary artery disease and in 30 healthy subjects. The correlation between serum HMGB1 levels and hs-CRP and cardiac troponin I levels was analyzed. Serum HMGB1 levels in patients with coronary artery disease were higher compared with those in healthy volunteers (63.5 +/- 15.29 vs. 21.98 +/- 4.33 mu g/l; P<0.01). Serum HMGB1 levels in patients with acute myocardial infarction were higher compared with those in patients with unstable and stable angina pectoris (77.53 +/- 6.86 vs. 63.67 +/- 8.6 and 44.39 +/- 9.01 mu g/l, respectively; both P<0.01). The levels of HMGB1 were positively correlated with hs-CRP and cardiac troponin I levels (r=0.657 and 0.554, respectively; both P<0.01) in patients with coronary artery disease. In conclusion, serum HMGB1 levels were elevated in patients with coronary artery disease, particularly in those with acute myocardial infarction. The levels of HMGB1 were correlated with the levels of hs-CRP and cardiac troponin I.

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页码：121 / 124

页数：4

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