Behavioral and Neurochemical Effects of Alpha-Lipoic Acid in the Model of Parkinson's Disease Induced by Unilateral Stereotaxic Injection of 6-Ohda in Rat

被引：26

作者：

de Araujo, Dayane Pessoa ^{[1
]}

Soares De Sousa, Caren Nadia ^{[1
]}

Pontes Araujo, Paulo Victor ^{[1
]}

de Souza Menezes, Carlos Eduardo ^{[1
]}

Sousa Rodrigues, Francisca Taciana ^{[1
]}

Escudeiro, Sarah Souza ^{[1
]}

Cortez Lima, Nicole Brito ^{[2
]}

Azevedo Patrocinio, Manoel Claudio ^{[2
]}

Vasconcelos Aguiar, Lissiana Magna ^{[1
]}

de Barros Viana, Glauce Socorro ^{[1
]}

Mendes Vasconcelos, Silvania Maria ^{[1
]}

机构：

[1] Univ Fed Ceara, Fac Med, Dept Physiol & Pharmacol, BR-60431270 Fortaleza, Ceara, Brazil

[2] Christus Fac Med, BR-60160230 Fortaleza, Ceara, Brazil

来源：

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2013年 / 2013卷

关键词：

ASPARTATE GLUTAMATERGIC AGONIST; OXIDATIVE STRESS; MONOAMINES CONCENTRATION; DOPAMINERGIC-NEURONS; LIPID-PEROXIDATION; NATURAL PHENOLICS; PREFRONTAL CORTEX; L-DOPA; 6-HYDROXYDOPAMINE; BRAIN;

D O I：

10.1155/2013/571378

中图分类号：

R [医药、卫生];

学科分类号：

100218 [急诊医学];

摘要：

This study aimed to investigate behavioral and neurochemical effects of alpha-lipoic acid (100 mg/kg or 200 mg/kg) alone or associated with L-DOPA using an animal model of Parkinson's disease induced by stereotaxic injection of 6-hydroxydopamine (6-OHDA) in rat striatum. Motor behavior was assessed by monitoring body rotations induced by apomorphine, open field test and cylinder test. Oxidative stress was accessed by determination of lipid peroxidation using the TBARS method, concentration of nitrite and evaluation of catalase activity. alpha-Lipoic acid decreased body rotations induced by apomorphine, as well as caused an improvement in motor performance by increasing locomotor activity in the open field test and use of contralateral paw (in the opposite side of the lesion produced by 6-OHDA) at cylinder test. alpha-lipoic acid showed antioxidant effects, decreasing lipid peroxidation and nitrite levels and interacting with antioxidant system by decreasing of endogenous catalase activity. Therefore, alpha-lipoic acid prevented the damage induced by 6-OHDA or by chronic use of L-DOPA in dopaminergic neurons, suggesting that alpha-lipoic could be a new therapeutic target for Parkinson's disease prevention and treatment.

引用

页数：13

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