Negative regulation of cytokine signaling: STAT-induced STAT inhibitor

被引：106

作者：

Naka, T ^{[1
]}

Fujimoto, M ^{[1
]}

Kishimoto, T ^{[1
]}

机构：

[1] Osaka Univ, Dept Med 3, Sch Med, Suita, Osaka 5650871, Japan

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1999年 / 24卷 / 10期

关键词：

D O I：

10.1016/S0968-0004(99)01454-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The growth and differentiation of cells that make up multicellular entities such as the blood and immune systems are under the control of glycoprotein mediators known as cytokines. These cytokines bind to membrane receptors on the cell surface and initiate a signaling cascade that ends with the transcription of specific sets of genes within the cell nucleus. Although knowledge is accumulating concerning the intracellular signal pathways that are activated by cytokines, little is known about inhibition of cytokine signals. This review will focus on the negative regulation of the Janus tyrosine kinase (JAK)/signal transducers and activators of transcription (STAT) signaling pathway by proteins related to STAT-induced STAT inhibitor-1 (SSl-1).

引用

页码：394 / 398

页数：5

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