SR-related proteins and the processing of messenger RNA precursors

被引：111

作者：

Blencowe, BJ ^{[1
]}

Bowman, JAL ^{[1
]}

McCracken, S ^{[1
]}

Rosonina, E ^{[1
]}

机构：

[1] Univ Toronto, Banting & Best Dept Med Res, CH Best Inst, Toronto, ON M5G 1L6, Canada

来源：

BIOCHEMISTRY AND CELL BIOLOGY | 1999年 / 77卷 / 04期

关键词：

SR protein; RNA polymerase; spliceosome; polyadenylation; nuclear matrix;

D O I：

10.1139/bcb-77-4-277

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The processing of messenger RNA precursors (pre-mRNA) to mRNA in metazoans requires a large number of proteins that contain domains rich in alternating arginine and serine residues (RS domains). These include members of the SR family of splicing factors and proteins that are structurally and functionally distinct from the SR family, collectively referred to below as SR-related proteins. Both groups of RS domain proteins function in constitutive and regulated pre-mRNA splicing. Recently, several SR-related proteins have been identified that are associated with the transcriptional machinery. Other SR-related proteins are associated with mRNA 3' end formation and have been implicated in export. We review these findings and evidence that proteins containing RS domains may play a fundamental role in coordinating different steps in the synthesis and processing of pre-mRNA.

引用

页码：277 / 291

页数：15

共 157 条

[1] THE YEAST MUD2 PROTEIN - AN INTERACTION WITH PRP11 DEFINES A BRIDGE BETWEEN COMMITMENT COMPLEXES AND U2 SNRNP ADDITION
ABOVICH, N
LIAO, XLC
ROSBASH, M
[J]. GENES & DEVELOPMENT, 1994, 8 (07) : 843 - 854
[2] Cross-intron bridging interactions in the yeast commitment complex are conserved in mammals
Abovich, N
Rosbash, M
[J]. CELL, 1997, 89 (03) : 403 - 412
[3] EXTENSIVE HOMOLOGY AMONG THE LARGEST SUBUNITS OF EUKARYOTIC AND PROKARYOTIC RNA-POLYMERASES
ALLISON, LA
MOYLE, M
SHALES, M
INGLES, CJ
[J]. CELL, 1985, 42 (02) : 599 - 610
[4] Protein of the SR family of splicing factors binds extensively to exonic Balbiani ring pre-mRNA and accompanies the RNA from the gene to the nuclear pore
AlzhanovaEricsson, AT
Sun, X
Visa, N
Kiseleva, E
Wurtz, T
Daneholt, B
[J]. GENES & DEVELOPMENT, 1996, 10 (22) : 2881 - 2893
[5] A DIFFERENTIALLY EXPRESSED MURINE RNA ENCODING A PROTEIN WITH SIMILARITIES TO 2 TYPES OF NUCLEIC-ACID BINDING MOTIFS
AYANE, M
PREUSS, U
KOHLER, G
NIELSEN, PJ
[J]. NUCLEIC ACIDS RESEARCH, 1991, 19 (06) : 1273 - 1278
[6] SPLICING OF BALBIANI RING-1 GENE PREMESSENGER RNA OCCURS SIMULTANEOUSLY WITH TRANSCRIPTION
BAUREN, G
WIESLANDER, L
[J]. CELL, 1994, 76 (01) : 183 - 192
[7] Molecular cloning of htra2-beta-1 and htra2-beta-2, two human homologs of tra-2 generated by alternative splicing
Beil, B
Screaton, G
Stamm, S
[J]. DNA AND CELL BIOLOGY, 1997, 16 (06) : 679 - 690
[8] SPLICE SITE SELECTION, RATE OF SPLICING, AND ALTERNATIVE SPLICING ON NASCENT TRANSCRIPTS
BEYER, AL
OSHEIM, YN
[J]. GENES & DEVELOPMENT, 1988, 2 (06) : 754 - 765
[9] The PWI motif: a new protein domain in splicing factors
Blencowe, BJ
Ouzounis, CA
[J]. TRENDS IN BIOCHEMICAL SCIENCES, 1999, 24 (05) : 179 - 180
[10] BLENCOWE BJ, 1995, RNA, V1, P852

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