Hypertrophic osteoarthropathy: Endothelium and platelet function

被引:36
作者
Silveri, F
DeAngelis, R
Argentati, F
Brecciaroli, D
Muti, S
Cervini, C
机构
[1] Department of Rheumatology, Ancona University, Ospedale A. Murri, 60035 Jesi (Ancona)
[2] Radioimmunology Service, Jesi Hospital, 60035 Jesi (Ancona), Viale della Vittoria
[3] Department of Rheumatology, Ospedale A. Murri, 60035 Jesi (Ancona)
关键词
hypertrophic osteoarthropathy; finger clubbing; platelet; endothelium; endothelin-1; beta-thromboglobulin; platelet-derived growth factor;
D O I
10.1007/BF02229639
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Hypertrophic osteoarthropathy (HOA) is characterized by finger clubbing, periostosis and arthritis, The pathogenesis of hypertrophic osteoarthropathy is still uncertain, Earlier studies have been focused on the potential role of platelet and endothelium in the pathogenesis of HOA. The aim of this study was to evaluate the circulating levels of endothelin-l (ET-1), beta-thromboglobulin (beta-TG) and platelet-derived growth factor (PDGF) in 21 HOA patients, The circulating levels of ET-1, beta-TG were significantly higher in HOA patients vs healthy controls, but not vs controls with lung diseases, On the contrary, PDGF was significantly higher in HOA patients vs healthy controls and vs subjects with lung diseases, These findings suggest that ''endothelium/platelet unit'' may play a role in the pathogenesis of HOA, and PDGF could induce the changes observed in HOA.
引用
收藏
页码:435 / 439
页数:5
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