GM-CSF Controls Nonlymphoid Tissue Dendritic Cell Homeostasis but Is Dispensable for the Differentiation of Inflammatory Dendritic Cells

被引：318

作者：

Greter, Melanie ^{[1
,2
]}

Helft, Julie ^{[1
,2
]}

Chow, Andrew ^{[1
,2
]}

Hashimoto, Daigo ^{[1
,2
]}

Mortha, Arthur ^{[1
,2
]}

Agudo-Cantero, Judith ^{[2
,3
]}

Bogunovic, Milena ^{[1
,2
]}

Gautier, Emmanuel L. ^{[2
,4
]}

Miller, Jennifer ^{[1
,2
]}

Leboeuf, Marylene ^{[1
,2
]}

Lu, Geming ^{[2
,5
]}

Aloman, Costica ^{[5
]}

Brown, Brian D. ^{[2
,3
,6
]}

Pollard, Jeffrey W. ^{[7
]}

Xiong, Huabao ^{[2
,5
,6
]}

Randolph, Gwendalyn J. ^{[2
,4
]}

Chipuk, Jerry E. ^{[1
,6
]}

Frenette, Paul S. ^{[7
]}

Merad, Miriam ^{[1
,2
,6
]}

机构：

[1] Mt Sinai Sch Med, Dept Oncol Sci, New York, NY 10029 USA

[2] Mt Sinai Sch Med, Inst Immunol, New York, NY 10029 USA

[3] Mt Sinai Sch Med, Genom Inst, New York, NY 10029 USA

[4] Mt Sinai Sch Med, Dept Dev & Regenerat Biol, New York, NY 10029 USA

[5] Mt Sinai Sch Med, Dept Med, New York, NY 10029 USA

[6] Mt Sinai Sch Med, Tisch Canc Inst, New York, NY 10029 USA

[7] Albert Einstein Coll Med, Bronx, NY 10461 USA

来源：

IMMUNITY | 2012年 / 36卷 / 06期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

COLONY-STIMULATING FACTOR; ANTIGEN CROSS-PRESENTATION; STEADY-STATE; MITOCHONDRIAL FISSION; MONOCYTE MIGRATION; DEFICIENT MICE; LYMPH-NODES; C-FMS; MACROPHAGE; REVEALS;

D O I：

10.1016/j.immuni.2012.03.027

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

GM-CSF (Csf-2) is a critical cytokine for the in vitro generation of dendritic cells (DCs) and is thought to control the development of inflammatory DCs and resident CD103(+) DCs in some tissues. Here we showed that in contrast to the current understanding, Csf-2 receptor acts in the steady state to promote the survival and homeostasis of nonlymphoid tissue-resident CD103(+) and CD11b(+) DCs. Absence of Csf-2 receptor on lung DCs abrogated the induction of CD8(+) T cell immunity after immunization with particulate antigens. In contrast, Csf-2 receptor was dispensable for the differentiation and innate function of inflammatory DCs during acute injuries. Instead, inflammatory DCs required Csf-1 receptor for their development. Thus, Csf-2 is important in vaccine-induced CD8(+) T cell immunity through the regulation of nonlymphoid tissue DC homeostasis rather than control of inflammatory DCs in vivo.

引用

页码：1031 / 1046

页数：16

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