The small peptide-catalyzed direct asymmetric aldol reaction in water

被引：180

作者：

Dziedzic, P

Zou, WB

Háfren, J

Córdova, A

机构：

[1] Stockholm Univ, Arrhenius Lab, Dept Organ Chem, S-10691 Stockholm, Sweden

[2] Swedish Univ Agr Sci, Dept Wood Sci, SE-75007 Uppsala, Sweden

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2006年 / 4卷 / 01期

关键词：

D O I：

10.1039/b515880j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Simple modular di- and tripeptides with a primary amine at the N-terminus catalyze the aqueous asymmetric aldol reaction between unmodified ketones and aldehydes to furnish the corresponding beta-hydroxy ketones with up to 86% ee in water and 99% ee in aqueos media.

引用

页码：38 / 40

页数：3

共 76 条

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