Traceless Directing Group for Stereospecific Nickel-Catalyzed Alkyl-Alkyl Cross-Coupling Reactions

被引：104

作者：

Greene, Margaret A. ^{[1
]}

Yonova, Ivelina M. ^{[1
]}

Williams, Florence J. ^{[1
]}

Jarvo, Elizabeth R. ^{[1
]}

机构：

[1] Univ Calif Irvine, Dept Chem, Irvine, CA 92697 USA

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 16期

关键词：

ASYMMETRIC-SYNTHESIS; STEREOGENIC CENTERS; CLINICAL-EVALUATION; GRIGNARD-REAGENTS; SUBSTITUTION; DERIVATIVES; INHIBITORS; ALDEHYDES; INSOMNIA; HALIDES;

D O I：

10.1021/ol300891k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Stereospecific nickel-catalyzed cross-coupling reactions of benzylic 2-methoxyethyl ethers are reported for the preparation of enantioenriched 1,1-diarylethanes. The 2-methoxyethyl ether serves as a traceless directing group that accelerates cross-coupling. Chelation of magnesium ions is proposed to activate the benzylic C-O bond for oxidative addition.

引用

页码：4293 / 4296

页数：4

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