Innate immune activation and cystic fibrosis

被引：25

作者：

Brennan, Siobhain ^{[1
]}

机构：

[1] Univ Western Australia, Ctr Child Hlth Res, Div Clin Sci, Telethon Inst Child Hlth Res, Nedlands, WA 6009, Australia

来源：

PAEDIATRIC RESPIRATORY REVIEWS | 2008年 / 9卷 / 04期

关键词：

cystic fibrosis; innate defence; neutrophil; macrophage; oxidative stress;

D O I：

10.1016/j.prrv.2008.05.008

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Since inflammation and infection occur so early in infancy In cystic fibrosis, the function of innate immune defence in cystic fibrosis has beer) questioned by many investigators. This review aims to summarize the findings relating to the physical, humoral and cellular components of innate immune defence in cystic fibrosis, and highlights the roles of neutrophils, macrophages and elpithelial cells in these activities. In addition, recently identified links between antioxidant defences and cystic fibrosis transmembrane conductance regulator (CFTR) function. and how these may impact on innate lung defence, are summarized. (C) 2008 Flsevier Ltd. All rights reserved.

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收藏

页码：271 / 280

页数：10

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