T lymphocyte responses in HIV-1 infection: implications for vaccine development

被引：100

作者：

Brander, C

Walker, B

机构：

[1] Massachusetts Gen Hosp, Partners AIDS Res Ctr, Charlestown, MA 02129 USA

[2] Harvard Univ, Massachusetts Gen Hosp E, Sch Med, Charlestown, MA 02129 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1999年 / 11卷 / 04期

关键词：

D O I：

10.1016/S0952-7915(99)80076-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Substantial progress has been made over the past year in understanding the cellular immune response in HIV pathogenesis. Cytotoxic T lymphocytes play a critical role in establishing the level of viremia and virus-specific Th cell responses appear to affect the in vivo efficacy of cytotoxic T lymphocytes. Together, these new data provide important insights to refocus efforts aimed at immunotherapeutic interventions and vaccine development.

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页码：451 / 459

页数：9

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