T lymphocyte responses in HIV-1 infection: implications for vaccine development

被引:100
作者
Brander, C
Walker, B
机构
[1] Massachusetts Gen Hosp, Partners AIDS Res Ctr, Charlestown, MA 02129 USA
[2] Harvard Univ, Massachusetts Gen Hosp E, Sch Med, Charlestown, MA 02129 USA
关键词
D O I
10.1016/S0952-7915(99)80076-4
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Substantial progress has been made over the past year in understanding the cellular immune response in HIV pathogenesis. Cytotoxic T lymphocytes play a critical role in establishing the level of viremia and virus-specific Th cell responses appear to affect the in vivo efficacy of cytotoxic T lymphocytes. Together, these new data provide important insights to refocus efforts aimed at immunotherapeutic interventions and vaccine development.
引用
收藏
页码:451 / 459
页数:9
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