A simple and versatile route to novel conjugated β-enaminonitriles and their application for the highly regioselective synthesis of nicotinonitriles using a Vilsmeier-type reagent

被引：30

作者：

Katritzky, AR ^{[1
]}

Denisenko, A ^{[1
]}

Arend, M ^{[1
]}

机构：

[1] Univ Florida, Dept Chem, Ctr Heterocycl Cpds, Gainesville, FL 32611 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1999年 / 64卷 / 16期

关键词：

D O I：

10.1021/jo990313g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A straightforward synthesis of conjugated beta-enaminonitriles from ketones and beta-aminocrotononitrile mediated by TiCl4 is described. The reaction of these novel dienamines with a Vilsmeier-type reagent provides a mild and highly regioselective route for the preparation of nicotinonitriles.

引用

页码：6076 / 6079

页数：4

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