Hunting for excitement: NMDA receptors in Huntington's disease

被引：9

作者：

Ellerby, LM ^{[1
]}

机构：

[1] Buck Inst Age Res, Novato, CA 94945 USA

来源：

NEURON | 2002年 / 33卷 / 06期

关键词：

D O I：

10.1016/S0896-6273(02)00631-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Excitotoxic cell death stimulated by quinolinic acid injection into the striatum has a long history of "mimicking" many aspects of motor, behavioral, and neurochemical changes observed in Huntington's disease patients. In this issue of Neuron, Zeron et al. (2002) provide insight into the role of NMDA receptors in the cell-specific excitotoxic death observed in Huntington's disease (HD) using a HD mouse model expressing full-length mutant huntingtin (htt).

引用

页码：841 / 842

页数：2

共 12 条

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