FXR: the key to benefits in bariatric surgery?

被引：27

作者：

Kuipers, Folkert ^{[1
]}

Groen, Albert K.

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Dept Pediat, NL-9700 AB Groningen, Netherlands

来源：

NATURE MEDICINE | 2014年 / 20卷 / 04期

关键词：

Y GASTRIC BYPASS; BILE-ACIDS; WEIGHT-LOSS; OBESITY; MICE; HOMEOSTASIS; GLUCOSE;

D O I：

10.1038/nm.3525

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bariatric surgery reduces the weight of morbidly obese individuals and exerts beneficial effects on associated metabolic disorders such as type 2 diabetes. However, despite growing traction in this area of metabolic research, questions remain as to the mechanisms that lead to these benefits. New findings propose that the bile acid–activated nuclear receptor FXR mediates the metabolic improvement seen after one particular bariatric surgery approach and that this may involve alterations in the microbiome.

引用

页码：337 / 338

页数：2

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