Carcinoembryonic antigen induces signal transduction in Kupffer cells

被引：23

作者：

Gangopadhyay, A ^{[1
]}

Lazure, DA ^{[1
]}

Thomas, P ^{[1
]}

机构：

[1] HARVARD UNIV,SCH MED,BETH ISRAEL DEACONESS MED CTR,DEPT SURG,LAB CANC BIOL,SWRL 3,BOSTON,MA 02215

来源：

CANCER LETTERS | 1997年 / 118卷 / 01期

关键词：

carcinoembryonic antigen; signal transduction; Kupffer cell;

D O I：

10.1016/S0304-3835(97)00216-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Carcinoembryonic antigen (CEA), an intercellular adhesion molecule and a mediator of hepatic metastasis, is processed by an 80 kDa receptor on murine and human Kupffer cells in the liver. Activation of rat Kupffer cells in vitro by CEA via the 80 kDa receptor produced cytokines IL-1 alpha and TNF-alpha which involved tyrosine phosphorylation. The peak response of TNF-alpha was 5.6 times greater than the corresponding IL-1 alpha response and was associated with enhanced tyrosine phosphorylation of 108 and 125 kDa proteins. Lipopolysaccharide (LPS) treatment, on the other hand, phosphorylated two major proteins with MW of 93 and 119 kDa associated with the loss of phosphorylation from a 125 kDa protein. Results demonstrate that CEA-induced IL-1 alpha and TNF-alpha production involves tyrosine phosphorylation and the signaling in CEA treated cells is different than that seen with LPS stimulation. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：1 / 6

页数：6

共 17 条

[1] CARCINOEMBRYONIC ANTIGEN, A HUMAN-TUMOR MARKER, FUNCTIONS AS AN INTERCELLULAR-ADHESION MOLECULE [J].